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PROCRIT is used to reduce or avoid the need for RBC transfusions.
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Kangas M, Bovbjerg DH, Montgomery GH: Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients.
Anemic patients (Hemoglobin greater than 10, to less than or equal to 12 grams per dL) who are scheduled to undergo elective non-cardiac, non-vascular surgery that are at high risk for perioperative transfusions (significant blood loss anticipated) in order to reduce the need for allogeneic blood transfusions (EPO only).
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If acidosis is present, sodium bicarbonate is helpful by increasing distal nephron sodium delivery, inducing kaliuresis, and promoting intracellular potassium shift.
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Adverse reactions were based on data from a randomized, double-blind, placebo-controlled study of darbepoetin alfa in 597 patients (darbepoetin alfa 301, placebo 296) with extensive stage small cell lung cancer (SCLC) receiving platinum-based chemotherapy.
Darbepoetin alfa administration was discontinued because of injection site pain in 2 patients and moderate hypertension in a third patient.
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Epoetin is used to treat severe anemia in patients with kidney disease.
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Effects of three kinds of erythropoiesis-stimulating agents on renal anemia in Japanese non-dialysis chronic kidney disease patients.
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Patients with end-stage renal disease (ESRD) are those patients with CRF who require regular dialysis or kidney transplantation for survival.
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