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De novo synthesized mediators include leukotrienes, prostaglandins, cytokines, and chemokines resulting in leukocyte recruitment including eosinophils, which characterize the late phase reaction.

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While more aggressive treatment is required to achieve remission in the case of SRNS of unknown cause (primary SRNS) to achieve remission, such an aggressive treatment is not effective for those with SRNSthat arises from genetic causes; therefore genetic testing may shield these children from the unnecessary side effects of immunosuppressive medications ().

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