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However, despite the attractiveness of this treatment option, the use of long-acting antipsychotics has fallen in recent years particularly in North America, likely as the result of the introduction and widespread use of the oral atypical antipsychotics.
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Indeed, in some studies QTc interval prolongation seen with risperidone LAI was even lower than with placebo.
Dehydration and associated hypoglycemia and electrolyte imbalance can cause delirium.
Follow your doctor's instructions carefully.
Moncreiff has further argued that the evidence for antipsychotics from discontinuation-relapse studies may be flawed, because they do not take into account that antipsychotics may sensitize the brain and provoke psychosis if discontinued, which may then be wrongly interpreted as a relapse of the original condition.
Besides this thorough examination of the drugs ingredients and performance, the FDA also conducts periodic inspections of the manufacturing plants to ensure there are no changes in the approved drugs quality.
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Although extensive metabolizers have lower risperidone and higher 9-hydroxyrisperidone concentrations, the pharmacokinetics of the active moiety (risperidone plus 9-hydroxyrisperidone) are similar after single and multiple doses in extensive and poor metabolizers.
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These persons, and body stuffers, are at high risk for toxicity as the drug wrapping may be compromised and allow complete drug absorption.
Pharmacologic treatment of agitation should be based on an assessment of the most likely cause for the agitation.
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In the late 1950s, initial federal controls were enacted; however, in spite of additional regulation and increased enforcement, amphetamines continued to be used by students, athletes, shift workers, long haul drivers, and for weight loss.
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The combination of improved efficacy and good tolerability may have important implications for patient compliance to therapy and subsequent positive long-term outcomes including the achievement of remission.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals.
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Open-label treatment was given for four months, followed by a two-month, placebo-controlled discontinuation phase, as described elsewhere.
Twice-daily administration also may minimize risk of orthostatic hypotension and syncope in geriatric patients and in patients with renal or hepatic impairment.
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Sedatives such as benzodiazepines (eg, diazepam) can cause or worsen the condition and are not usually used, although they can help when the delirium is caused by alcohol withdrawal.
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