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Amisulpride has one of the lowest potentials for weight gain of all the antipsychotic agents, and is clearly associated with lower use of anti-parkinsonian medication and with fewer dropouts due to adverse events than conventional antipsychotics.
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Randomized comparisons of a mood stabilizer (lithium or valproate), alone or in combination with antipsychotics, generally found that the combinations were superior to monotherapy for the rapid control of manic symptoms.
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Amisulpride-treated patients also demonstrated better functional improvement than those given risperidone.
Moreover, since mostly short-term results were available, longer-term risk for more distal outcomes, such as diabetes and cardiovascular illness, were not available in first-episode patients, except for a data base study().
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It works like an antipsychotic on dopamine receptors but it also works on serotonin receptors as well.
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Some of our study data, and in particular the overcoming of depressive episodes after decreasing the amisulpride dosage, suggest that this compound may be effective as an antidepressant at low doses and as an antimanic at high doses, properties that could be used in long-term treatment of the bipolar disorder.
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