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Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of other drugs and may not reflect the rates observed in practice.
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The known-groups method compares scale scores across groups known to differ in the health construct being investigated.
Adverse reactions were determined based on pooled data from 5 randomized, active-controlled studies of darbepoetin alfa with a total of 1357 patients (darbepoetin alfa 766, epoetin alfa 591).
When data from all patients in the US phase 3 multicenter trial were analyzed, there was an apparent trend of more reports of hypertensive adverse events in patients on dialysis with a faster rate of rise of hematocrit (greater than 4 hematocrit points in any 2-week period).
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Additional analyses will be needed to determine the specific mechanisms of hyporesponsiveness in the patients in our study.
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Patients should have a CBC performed as part of the pretreatment assessment since adverse reactions of combination HCV treatment include anemia, neutropenia, and thrombocytopenia.
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From this point your product is only 8-21 days (depending on the shipping method chosen) from arriving at your home or office.
FDA has yet to clarify the requirements for interchangeability, although the agency has stated that it highly recommends that sponsors use a two-step process for obtaining the interchangeable biologic designation, first gaining approval as a biosimilar and then submitting a supplement with new data to support interchangeability.
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Treatment should be discontinued if the hematocrit exceeds 40%.
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In summary, the current analysis makes use of a large contemporary dataset that reflects current trends in the management of HD patients in the United States to evaluate the effect of varying levels of TSAT and ferritin in predicting Hb response to ESA.
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The primary targets of HIV are cells with the CD4 surface protein, including principally helper T lymphocytes.
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Injection, epoetin alfa, 1000 units (for esrd onNon-active code 2016 HCPCS J0886: Injection, epoetin alfa, 1000 units (for esrd on dialysis).
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Department of Medicine, University of Texas Southwestern Medical Center, Dallas (R.
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Particular caution should be exercised in the use of epoetin or darbepoetin concomitant with chemotherapeutic agents and diseases where risk of thromboembolic complications is increased.
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In the PIONEER study, Zarxio and the reference product both produced the expected reduction in the duration of severe neutropenia in cancer patients undergoing myelosuppressive chemotherapy (1.
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An indistinct balance: the safety and efficacy of parenteral iron therapy.
The dialysis will help in ridding the body of fluid and toxins that it is unable to process and excrete on its own.
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If possible, HIV regimens should be stable and no further changes in the antiretroviral regimen anticipated when initiating HCV therapy.
This worldwide guideline is also expected to advise clinical trials to establish safety and efficacy.
When adjusting therapy consider hemoglobin rate of rise, rate of decline, ESA responsiveness and hemoglobin variability.
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Epoetin alfa injection comes as a solution (liquid) to inject subcutaneously (just under the skin) or intravenously (into a vein).
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The level of RANKL expression does not linearly correlate to the effect of this ligand.
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Patients who are treated with BEACOPP should receive long-term follow-up care to monitor for side effects from this therapy.
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Unfortunately, some athletes and their coaches were eager to abuse rHuEpo because it increases the O 2 supply to the muscles and boosts performance in endurance sports such as skiing, running and cycling.
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If your doctor suspects you have a myelodysplastic syndrome, you may be referred to a doctor who specializes in blood disorders (hematologist).
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When anemia is caused by a correctable pathology such as iron or folate deficiencies, hemolysis or an occult or overt blood loss, EPO or DPO are not medically necessary and are not covered.
No drug interactions have been studied by the manufacturer.
The patient is HIV-positive and has anemia related to zidovudine therapy.
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FACIT questionnaires can be administered by self-report (paper or computer) or interview (face-to-face or telephone).
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